Tailored Care for Patients With CML: Expert Guidance on Therapy Selection to Improve Patient Outcomes

Tailored Care for Patients With CML: Expert Guidance on Therapy Selection to Improve Patient Outcomes is organized by Clinical Care Options (CCO), LLC.,Released: March 16, 2023,Expiration: March 15, 2024,Program Learning Goal:,The goal of this activity is to improve the competence of all members of the interdisciplinary team in applying the latest guidance and clinical data in the management of individuals with chronic myeloid leukemia.,Learning Objectives:,After completing this activity, participants should be better able to:,• Compare the mechanisms of actions of available TKIs to block BCR::ABL activity and the associated toxicity profiles of these agents when used to treat patients with CML,• Increase patient involvement in the initiation of treatment, monitoring of response, managing toxicity, and optimizing adherence,• Select individualized therapy for patients with chronic-phase CML, considering patient goals, age, medical history, comorbidities, risk score, previous CML treatment, and BCR::ABL1 mutation status,• Monitor treatment responses and determine optimal timing for therapy changes,• Evaluate the available evidence, potential predictive factors, patient preferences, and expert recommendations guiding potential therapy discontinuation and treatment-free remissions,• Optimally sequence second-line, third-line, and later therapeutic strategies to overcome resistance after previous TKI failure