Mitochondria Signaling and Disease

Mitochondria Signaling and Disease is organized by Keystone Symposia on Molecular and Cellular Biology and will be held from Feb 12 - 15, 2024 at Fairmont Banff Springs, Banff, Alberta, Canada.,Description:,Mitochondria play complex roles in cellular physiology and homeostasis that have profound impacts on human health and disease. Fundamental insights have been gained from cell biology approaches that led to a deeper understanding of mitochondria as signaling platforms and metabolic engines that drive changes in cell fate. The challenge has been to understand these roles in a holistic and inclusive way, a task that often requires multidisciplinary and the development of new technologies to bridge gaps in the field. ,,The primary goal of this symposium is to highlight exiting new areas of mitochondrial research, focused on ,• aspects of mitochondrial dynamics and quality control, ,• mitochondrial contributions to metabolic rewiring in cell fate decisions, and ,• links between mitochondria and immunity with intriguing new discoveries of mitochondrial transfer between cells. ,,We will focus on the impact and mechanisms of mitochondrial behavior in a variety of contexts including cancer metabolism, inflammation, neurodegenerative disease and metabolic disorders led by established and emerging experts in the field. Understanding how mitochondria relay intracellular signals in the control of cell fate changes and within homeostasis remains a major challenge. As much of this signaling involves contact sites with other organelles the meeting will be held in parallel with a contact site symposium that will examine metabolic flux in the broadest context. Interactions between scientists at all levels will provide new opportunities for collaboration as we move to integrate our findings into a deeper understanding of mitochondrial contributions to health and disease.