AM22-50-O: (On-Demand) Serologic and Molecular Challenges Within the Rh Blood Group System (Enduring)
AM22-50-O: (On-Demand) Serologic and Molecular Challenges Within the Rh Blood Group System (Enduring) is organized by Association for the Advancement of Blood & Biotherapies (AABB).
Expiration Date: Dec 31, 2024
Description:
The Rh blood group system is very complex. At the molecular level, hundreds of variant alleles are known that cause weak or partial expression of Rh antigens, the expression of low-prevalence antigens, or the production of an Rh protein that lacks a high-prevalence antigen. In serology, autoantibodies or mimic antibodies, in addition to alloantibodies, may appear to have Rh specificity. In this session we discuss some of the challenges associated with the Rh blood group system and how, using both serology and molecular assays, we can provide the most appropriate transfusion recommendations and improve patient care. This session will be offered exclusively in Spanish.
The Rh blood group system is highly complex. On a molecular level, hundreds of variant alleles are known to cause weak or partial expression of Rh antigens, the expression of low prevalence antigens, or the production of an Rh protein lacking a high prevalence antigen. In serology, autoantibodies or mimicking antibodies, in addition to alloantibodies, may appear to have Rh specificity. In this session, we discuss some of the challenges associated with the Rh blood group system, and how utilizing both serology and molecular assays, we can provide the most appropriate transfusion recommendations and improve patient care. This session will be offered entirely in Spanish.
All relevant financial relationships have been mitigated.
Learning Objectives:
•Describes serologic strategies to distinguish Rh alloantibodies from autoantibodies with Rh specificity, especially in cases of recent transfusion or when variant expression of Rh antigens is suspected variant expression of Rh antigens is suspected.
• Discuss cases where RH DNA analysis can complement serologic testing to better guide transfusion recommendations. / Discuss cases in which DNA analysis for RH can complement serological testing to better guide transfusion recommendations.
• Explain the process of discovery of a novel RH allele, including how to ascertain clinical significance. / Explain the process of discovering a new RH allele, including how to determine clinical significance.
