New Roles of Carboxypeptidase E in Endocrine and Neural Function and Cancer
hosted byOpus Medicus, Inc.
New Roles of Carboxypeptidase E in Endocrine and Neural Function and Cancer is organized by Opus Medicus, Inc.
Dates:
Released date: 08-Aug-2017
Last Review Date: 07-Aug-2021
Expiration Date: 06-Aug-2024
Topics:
• Introduction to functions of CPE
• The CPE gene, biosynthesis, protein structure and distribution
• CPE in prohormone sorting and vesicle transport
• CPE action in the endocrine system - insights from mouse models
• CPE in neural function and behavior
• CPE and cancer in humans
• Human CPE genetic mutations and disease
• Conclusions
• Future directions
Course Description:
This course reviews the phylogeny, structure and function of Carboxypeptidase E (CPE) in hormone and neuropeptide sorting and vesicle transport for secretion, alternative splicing of the CPE transcript and single nucleotide polymorphisms in humans. The course presents findings of important roles for CPE in the modulation of metabolic and glucose homeostasis, bone remodeling, obesity, fertility, neuroprotection, stress, sexual behavior, mood and emotional responses, and learning and memory. In addition, the course describes a splice variant form of CPE that has recently been found to be an inducer of tumor growth and metastasis, and a prognostic biomarker for metastasis in endocrine and non-endocrine tumors.
Objectives:
• Participants completing this course will gain an understanding of:
• The phylogeny, structure and function of Carboxypeptidase E (CPE) in hormone and neuropeptide sorting and vesicle transport.
• Important roles for CPE in metabolic functions.
• The connection between a variant of CPE and tumor growth and metastasis.
