Contemporary approaches to advanced diffuse large B-cell lymphoma (DLBCL)

In this online CME self-learning program:

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma (NHL), making up just under a third of NHL cases. In the United States, there are roughly 7 cases of DLBCL per 100,000 patients per year. The pathophysiology of DLBCL is complex and not fully understood; but is characterized by a widespread increase of very large, mature B-cells arising from various gene mutations. DLBCL is heterogenous group of tumors and includes many diverse subtypes based on location, presence of other cells within the tumor, and whether the patient has other related illnesses. Advanced age, immunodeficiency, and Epstein-Barr virus are associated risk factors for DLBCL. The disease is considered an AIDS-defining malignancy, marking the point at which an HIV infection is considered AIDS. Diagnosis of DLBCL is made by a tissue biopsy, and morphology and immunophenotyping play a crucial role in determining which subtype of DLBCL a patient has.

This program is supported by educational grants from Seattle Genetics.

This activity is free of charge.

Release Date: December 22, 2020 -- Expiration Date: December 22, 2022

Faculty: Carla Casulo, MD

Agenda

Epidemiology and diagnosis of DLBCL

·      ~ The most affected: A demographic review

·      ~ Risk factors

·      ~ Clinical features, presentation, and pathophysiology

·      ~ Prognostic significance of phenotypic and cytogenetic features

·      ~ Patient case(s)

Management of DLBCL: Contemporary guidelines, agents, and monitoring

·     ~ Clinical considerations

·     ~ Germinal center vs. activated B cell types R-CHOP

·     ~ Double hit, double expressor

·     ~  First-line therapies and beyond

·     ~ Treatment mechanisms and toxicities

·     ~ Monitoring and outcomes

·     ~ Alternative approaches in special populations: elderly adults, coexistent with or with features intermediate to other lymphomas

·     ~ Complications and their management

·     ~ Investigational and emerging therapies

·     ~ Best practice and clinical pearls

·     ~ Patient cases

Summary, conclusions, and best practice recap

Learning Objectives

By the end of the session the participant will be able to:

• ~ Describe present approaches to the clinical management of patients with DLBCL and apply them to patient cases.
• ~ Discuss the risk-benefit profiles of current and emerging therapies for the treatment of DLBCL.
• ~ Recall clinical challenges associated with treating special subpopulations of patients with DLBCL, including high-risk groups.

Accreditation

ScientiaCME is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation: ScientiaCME designates this educational activity for a maximum of 0.75 AMA PRA Category 1 Credit(s)™ toward the AMA Physician's Recognition Award. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Physicians: For maintenance of certification (MOC) credit, you must enter your board certification ID # and birth date correctly. It is the learner's responsibility to provide this information completely and accurately at the completion of the activity. Without providing it, the learner will NOT receive MOC credit for this activity. Please note: not all activities on this site provide MOC credit. If this activity does not specify that it provides MOC credit in this section, then it does NOT provide MOC credit.

Pharmacists

ScientiaCME is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmaceutical education. This program is approved for 0.75 hours (0.075 CEUs) of continuing education.  Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks to participants who have successfully completed the post-test.  Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit. ACPE # 0574-0000-20-057-H01-P. ACPE Accreditation effective 12/22/20, expires 12/22/22. This is a Knowledge (K)-type activity.

Pharmacists: You must enter your NABP # and birth date correctly so that proof of participation can be posted to your NABP CPE profile. It is the learner's responsibility to provide this information completely and accurately at the completion of the activity. Without providing it, the learner will NOT receive CPE credit for this activity.

Nurse Practitioners (NPs): The American Academy of Nurse Practitioners accepts AMA PRA Category 1 Credit(s)™ from organizations accredited by the ACCME. ScientiaCME will provide NPs who successfully complete each activity with a certificate of participation indicating that the activity was designated for AMA PRA Category 1 Credit(s)™.

Physician Assistants: The American Academy of Physician Assistants accepts AMA PRA Category 1 Credit(s)™ from organizations accredited by the ACCME.

Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.

Faculty Disclosure: Carla Casulo, MD, Assistant Professor, Department of Medicine, Division of Hematology and Oncology, University of Rochester, has no relevant financial disclosures.

Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, CEO of ScientiaCME, has no relevant financial disclosures.

Commercial Support Disclosure: This program is supported by educational grants from Seattle Genetics.

Instructions

• ~ Read the learning objectives above
• ~ Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowedge gained by participating in this CME activity.
• ~ View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
• ~ Take the post-test
• ~ Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

System Requirements

PC

Windows 7 or above

Internet Explorer 8

*Adobe Acrobat Reader

MAC

Mac OS 10.2.8

Safari or Chrome or Firefox

*Adobe Acrobat Reader

Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version