2021 CPIP-H Case 8: Coagulation – Prolonged Prothrombin Time With Prolonged Activated Partial Thromboplastin Time: Pitfalls and Pearls for the Practicing Pathologist
2021 CPIP-H Case 8: Coagulation – Prolonged Prothrombin Time With Prolonged Activated Partial Thromboplastin Time: Pitfalls and Pearls for the Practicing Pathologist is organized by College of American Pathologists (CAP).
Launch Date: August 16, 2021
Expiration Date: August 15, 2024 12:00 AM (ET)
Description:
This activity highlights the impact of preanalytical variables on prothrombin time (PT) and activated partial thromboplastin time (aPTT) testing and role of these tests in preoperative evaluation. To help pathologists in their consultative role, a practical algorithm for interpretation of mixing studies for prolonged PT and aPTT is provided along with an overview of vitamin K deficiency, coagulopathy of liver disease, and disseminated intravascular coagulation.
Objectives:
After completing this activity, you should be able to:
• Describe preanalytical variables that affect prothrombin time (PT) and activated partial thromboplastin time (aPTT).
• Recognize professional organization guidelines regarding coagulation screening tests in the preoperative setting.
• List causes of prolonged PT and aPTT and understand the role of mixing studies in the differential diagnosis.
• Differentiate between vitamin K deficiency, disseminated intravascular coagulation (DIC), and coagulopathy of liver disease.